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Bupropion Weight Loss
Bupropion
weight loss is an off-label prescription
Bupropion weight loss
is an "off-label" use of buprion which is specifically approved as an
anti-depressant drug. It is associated with clinically
significant weight loss of about 5 pounds in 8 weeks.
Bupropion
is also approved as a smoking cessation drug. The drug is marked as
Wellbutrin the antidepressant and Zylon the smoking ceasation
drug.
Bupropion
weight loss
like other approved
weight loss medication like phentermine weight loss
and sibutramine weight loss is
also a central nervous system stimulant. It affects neurotransmitters
in the brain inhibiting the feeling of hunger. However unlike them, it
mainly affects dopamine and norepinephrine rather than
serotonin.
Neurotransmitters
are brain chemicals used to send messages with the central nervous
system and the brain. They are released by nerve cells and stimulate
reception on other cells. Once the message is sent, the
neurotransmitters are destroyed or absorbed into the cell that produced
them. This is technically referred to as neurotransmitters re-uptake.
Bupropion affects dopamine and norepnehrine by inhibiting the
re-uptake.
Inhibited
re-uptake results to the message of the neurotransmitter to be
sustained as well as amplified. Dopamine and norepinephrine tend to
amplify and sustain the feeling of fullness or satiety.
A
study with the sustained release formulation of Bupropion in
combination with lifestyle intervention i.e. energy restricted diet and
exercise resulted to significant weight loss in obese patients in a 24
week trial. The study further showed that the same regime could sustain
the weight up to 48weeks.Obviously further studies on bupropion weight
loss are necessary to ascertain it’s safety and efficiency on
weight loss. Meanwhile some doctors continue to prescribe it for weight
loss.
Bupropion
was invented back in 1966 by Burrough Research who are today known as
Glaxo SmithKline. It was patented in 1974 meaning its patent ended in
2004 making Bupropion generic available. It was approved as an
antidepressant drug by the US FDA in 1974.It was again approved this
time as an anti smoking drug in 1997.
Bupropion
shows wide possibilities because it is being investigated not only for
weight loss but also Attention Deficient Hyperactive Disorder (ADHD) as
well as Restless Leg Syndrome. Recently it was approved for Seasonal
Affective Disorder.
Though
not approved for the following it is prescribed "off-label" for bipolar
depression, Arthritis, Chronic fatigue, irritable bowel syndrome and as
a bupropion weight loss.
For
weight loss the dosage reported for Bupropion SR (sustained release)
are 400mg/day and 300mg/day during 24 weeks. Bupropion showed an extent
of dose dependant effect in weight loss. 400mg/day resulted to 10% loss
of total body weight and 300mg/day resulted to 7.2% compared to a
control that had only 5.0%.
Note
the control was a diet and exercise only and the other were diet,
exercise and bupropion. And though the higher dosage had better results
it also had the most side effects.
Always,
drugs need to be used as adjuncts to a weight loss diet as well as
weigh loss exercises.
Fat Loss 4 Idiots (lose 40 lbs with Calorie Shifting )
refers to such adjuncts as support structures.
Side Effects of Bupropion Weight Loss
Common side effects of bupropion include
headaches, dry mouth and
diarrhea. Others are excitement, anxiety, dizziness, vomiting, tremor,
constipation and excessive sweating.
Some of the serious side effects include seizures, confusion,
hallucinations, irrational fear, fever, severe skin rash, itching,
swelling of face, throat, tongue, lips, eyes, ankles or lower legs,
hoarseness muscle or joint pains and irregular heart beats.
Higher
doses show higher cases of side effects. In particular, Bupropion has
show suicidal thought in children and adolescents. It should not be
used for these age groups. Fortunately for bupropion weight loss the
dosage needed to effect weight loss is less that that used for treating
depression for which the drug is approved.
Like
other drugs, bupropion does interact with some prescription and
non-prescription drugs as well as Vitamins and herbs so you need to
inform your doctor of anything you are taking.
Weight
loss drugs are used only in obese patients who are not responding to
other life intervention methods. And just to know, they are never used
alone, you need to combine them with low energy diet and preferably
exercises and behavioral treatment.
Drugs
are not the only support structures available.
Fat Loss 4 Idiots (lose 40 lbs with Calorie Shifting )
details other tactics to help you support
your dieting endeavor.
In the next page, you learn about Calorie Shifting You will discover;
Weight loss is based on science but you need to execute it
artistically. You need to know when to apply which principle to apply
when. So, in addition this Calorie Shifting will show you . . .
Next Page:
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To
learn more on Bupropion Weight Loss as well
as related
subjects use the links below.
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you can use the Google search tool further below.
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