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Fenfluramine Weight Loss
Fenfluramine
for weight loss is no longer available
Fenfluramine
weight loss
is another amphetamine used with little success for weight loss.
As a weight
loss medication it had only fair effect on weight but a host
of undesirable side effects.
Medical
intervention using a drug like fenfluramine weight loss
may be
necessary to individuals showing resistance to the
conventional weight loss method.
It is adviced to use weight loss drugs
strictly on the
morbidly obese. And even this as more of a last resort, because drugs often carry side effects.
As an alternative, one can choose to use a diet supplement based program like
Hoodia
Weight Management Program (Try it FREE, watch the
video)
which is are generally safer and many time more effective compared to drugs.
Fenfluramine
and a related drug dexfenfluramine have since 1997 been pulled out of
the markets in the U.S. They are probably unavailable as weight loss pills
in most countries.
Dexfenfluramine
is what is called an eutomer of fenfluramine. An eutomer is a mirror
image of another chemical structure. This is similar to your left and
right hand that are basically the same but structurally opposite
(mirror image)
Both
fenfluramine and dex-fenfluramine have been tried as solo drugs for
treating obesity. However they grew in popularity when they were used
in an "off-label" co-administration with phentermine weight
loss another drug. The resulting cocktail, Phen-Fen
and Dexfen-Phen resulted to a more effective weight loss drug, or so we
thought.
As
early as 1973, fenfluramine weight loss was being sold as a medication
by the brand name Pondimin after approvals by FDA. It was also
available in Europe in the early 1990’s before its famed rise
as part of the "magic diet pill" phen-fen in 1996. It was marketed as
Isomeride.
Isomeride
was a non-addictive drug containing fenfluramine derivatives.
Later
dexfenfluramine was approved for use in the U.S in 1996 and marketed as
Redux, sparking of the phen-fen revolution.
Fenfluramine Weight Loss Mechanism of Action
Fenfluramine unlike other appetite suppressants
release into the body
extra amounts of serotonin. Serotonin is a neurotransmitter a brain
chemical/messenger that is associated with satiety and a feeling also
acted as a re-uptake inhibitor.
Neurotransmitters
are brain chemical that carry messages within the brain. Since nerves
do not physically connect to each other they send message across a
synapses to the next cell using these chemicals. The message is picked
up by the other nerve cell using receptors. Once the message has been
passed the neurotransmitters are either destroyed or absorbed into the
cell that produced them. This is done to stop the message.
The
process of absorbing is called re-uptake. When re-uptake is inhibited,
the effect of the neurotransmitter (the message) is amplified and also
sustained. One of the effects of message of this neurotransmitter is a
sense of fullness. Serotonin is one of these
neurotransmitters.
This
double effect of stimulating as well as inhibiting serotonin re-uptake
is suggested to be the reason behind the more sever side effect of
fenfluramine.
In
the mid 1990’s fenfluramine was prescribed "off-label" with
phentrmine. For a while the resulting cocktail phen-fen seemed like the
panacea to the epidemic obesity of the west, until it was linked to
serious heart valve disease and an often fatal Primary Pulmonary
Hypertension (PPH).
Today,
fenfluramine and dex-fenfluramine are not used in weight loss drugs.
Their side effects are considered to adverse compared to their
benefits. Both Fen and Dexfen have been linked to heart valve disease
though to a lesser extent than their cocktail phen-fen.
When
a doctor chooses to include a medication into your weight loss program,
they basically consider the potential side effects against the risk of
obesity. But you can use some diet pill help without having to
deal with the risk of side effects. The diet supplemets based
Hoodia
Weight Management Program (Try it FREE, watch the
video)
is often safer and more effective than
most drugs.
Watch the short
video above by clicking any link below. You
will see what people using Hoodia based weight loss program
have to say. Discover...
If you are battling with eating excessive calories, hunger pangs when
dieting or cravings that make you fail in losing weight, then
seriously consider the Hoodia
Weight Management Program. It will help you deal
with the intake of excessive calories, guaranteeing you easy weight
loss. So, in addition you will get answers to the following
questions....
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